HPE ProLiant DL380 Gen10 Plus – 8 Bay LFF 8 x 3.5 Drive bays. Dual Xeon Gen3 Processor Server. 3x PCIE Slots.
Description
The HPE ProLiant DL380 Gen10 8SFF P06422-B21 server offers powerful performance, next-gen security, and exceptional scalability for modern data centers. Powered by an Intel® Xeon® Gold 5118 processor and equipped with 64GB DDR4 memory, this 2U rack server is engineered for versatility—whether you’re deploying on-premise, in the cloud, or in a hybrid IT environment. Its modular 8-bay Small Form Factor (SFF) design, dual redundant 800W power supplies, and support for up to two CPUs make it ideal for virtualization, AI, deep learning, and big data analytics.
- Powered by 2x Intel Xeon Scalable Processor Gen3 3rd Generation Intel Xeon Gold Scalable Processor, 3rd Generation Intel Xeon Platinum Scalable Processor and 3rd Generation Intel Xeon Silver Scalable Processor Processors
- Supports up to 32 modules of Registered DIMMs (RDIMMs), Load Reduced DIMMs (LRDIMMs), Intel Optane Persistent Memory for HPE and HPE DDR-4 Blank Kit Memory
- 3x PCI Expansion Slots configurable with 1 Gigabit Ethernet adapters, 10 Gigabit Ethernet adapters, 25 Gigabit Ethernet adapters, HPE InfiniBand, Fibre Channel HBAs and CNAs, 100 Gigabit Ethernet Adapters and 200 Gigabit Ethernet Adapters
- Delivering a boost in storage, compute and expansion performance, the adaptable HPE ProLiant DL380 Gen10 Plus server range provides you with the right combination of expandability and scalability.
- Designed and built for versatility and resiliency, the dual socket DL380 Gen10 Plus server range is deployable in a variety of environments and powered by 3rd Gen Intel Xeon Scalable processors.
Features
- Processor: Intel Xeon Gold 5118 (12-core, 2.3 GHz)
- Memory: 64 GB DDR4 SDRAM (2 x 32 GB), expandable to 3 TB
- Form Factor: 2U Rackmount
- Drive Bays: 8 Large Form Factor (LFF) bays supporting 3.5″ drives
- Controller: HPE Smart Array P408i-a SR Gen10 (12Gb/s SAS, RAID support)
- GPU Support: Up to 7 single-width or 6 full-height GPUs
- Network: Embedded 4 x 1GbE, FlexibleLOM support (up to 40GbE)
- Expansion Slots: Multiple PCIe 3.0 slots for additional networking/storage
- Power: Dual 800W redundant PSUs
Storage & Performance
- Hot-Swap Capability: All 8 LFF bays support hot-swappable drives for easy maintenance and upgrades
- Storage Controller Options: Compatible with HPE Smart Array Controllers supporting Trimodal (NVMe/SAS/SATA) configurations
- NVMe Support: Optional NVMe support for high-speed storage performance
- Powered by 3rd Gen Intel Xeon Scalable Processors: Delivers high compute performance for intensive applications.
- PCIe Gen4 Support: Offers improved bandwidth and throughput compared to previous generations.
- Support for NVIDIA GPUs: Compatible with NVIDIA T4 and A10 GPUs, ideal for AI, deep learning, and virtual workstation workloads
Versatility
- Designed for multi-workload compute environments, offering high scalability and reliability.
- Ideal for data centers, virtualization, database hosting, and enterprise applications.
Networking & Connectivity
- OCP 3.0 Network Adapter Support: Enables flexible and high-speed networking options
- Integrated Lights-Out (iLO): HPE iLO 5 provides remote management, monitoring, and automation capabilities
Security & Reliability
- End-to-End Security: Built-in security features from manufacturing to decommissioning
- Resilient Design: Engineered for high availability and reliability across diverse workloads
Intelligent Management
- BIOS Optimization: Real-time feedback and recommendations for BIOS tuning, Integrated Lights-Out (iLO) for remote management
- Automation: Streamlined provisioning and maintenance through software-defined control
- HPE iLO Mobile App for 24/7 access from mobile devices
Redundant, Efficient Power Supply
Comes with 2 x 800W redundant power supplies, offering failover protection and high efficiency under variable load conditions. Perfect for 24/7 enterprise environments requiring consistent uptime.
Advanced Security Architecture
HPE’s Silicon Root of Trust, Server Configuration Lock, and Runtime Firmware Verification deliver end-to-end security from boot to firmware. Enhanced features like iLO 5 Security Dashboard and Secure Recovery provide visibility and integrity throughout the server lifecycle.
Deal Use Cases
- Virtualization (VMware, Hyper-V) and Private Cloud
- Supports large memory capacity and PCIe 4.0 for faster I/O.
- Ideal for running multiple virtual machines or containers.
- Great for businesses transitioning from Gen10 hardware needing performance boosts
- Storage-Heavy Applications
- The 8 LFF bays allow for high-capacity HDDs or SSDs, making it suitable for:
- File servers
- Backup and disaster recovery
- Archival storage
- Excellent for hybrid cloud deployments using NVMe drives.
- The 8 LFF bays allow for high-capacity HDDs or SSDs, making it suitable for:
- Data Analytics and Big Data
- With support for Intel Xeon Scalable processors and up to 6 TB of DDR4 memory, it’s well-suited for:
- Real-time analytics
- Business intelligence workloads
- Data warehousing
- With support for Intel Xeon Scalable processors and up to 6 TB of DDR4 memory, it’s well-suited for:
- Enterprise Applications
- Reliable for running ERP, CRM, and database systems.
- Enhanced security features like TPM 2.0 and Silicon Root of Trust make it ideal for sensitive workloads.
- GPU-Accelerated Workloads
- Supports up to 4 double-width GPUs, making it viable for:
- AI/ML model training
- VDI (Virtual Desktop Infrastructure)
- High-performance computing (HPC).
- Supports up to 4 double-width GPUs, making it viable for:
- Branch Office or Remote Site Deployment
- Compact 2U form factor with robust remote management via iLO 5.
- Great for distributed environments needing centralized control











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